RM3115

SIGIRR (11V5) Rabbit Monoclonal Antibody

TIR8; IL-1R8

常规抗体

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic peptide of human SIGIRR

WB: 1:1000-1:5000

46kDa

46kDa

-20°C/1 year

Rabbit

IgG

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Affinity Purification