RM3098

Phospho-ErbB 4 (Tyr1162) (1R16) Rabbit Monoclonal Antibody

HER4; ALS19; p180erbB4

常规抗体

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic phosphopeptide corresponding to residues surrounding Tyr1162 of human ErbB 4

WB: 1:2000-1:10000 IHC: 1:50 IP: 1:20

180kDa

147kDa

-20°C/1 year

Rabbit

IgG

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Affinity Purification