产品名称
STAP2 Rabbit Polyclonal Antibody
蛋白名称
Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UGK3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UGK3/entry
Mouse Swissprot No.
Q8R0L1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R0L1
免疫原
Synthesized peptide derived from part region of human protein
特异性
STAP2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008],
功能
function:Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.,PTM:Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.,sequence caution:Alu insert from position 358 to 403.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with PTK6 and CSF1R.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
