产品名称
BIN2 Rabbit Polyclonal Antibody
蛋白名称
Bridging integrator 2 (Breast cancer-associated protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBW5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBW5/entry
Mouse Swissprot No.
D3Z6Q9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/D3Z6Q9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q68FR2
免疫原
Synthesized peptide derived from human protein . at AA range: 260-340
特异性
BIN2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
induction:Up-regulated during monocytic differentiation.,similarity:Contains 1 BAR domain.,subunit:Interacts with BIN1.,tissue specificity:Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.,
组织表达
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
细胞定位
Cytoplasm . Cell projection, podosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cell cortex . Cell projection, phagocytic cup . Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. .
功能
induction:Up-regulated during monocytic differentiation.,similarity:Contains 1 BAR domain.,subunit:Interacts with BIN1.,tissue specificity:Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.