产品名称
HNF6 Rabbit Polyclonal Antibody
蛋白名称
Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBC0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBC0/entry
Mouse Swissprot No.
O08755
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08755
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P70512
免疫原
Synthesized peptide derived from human protein . at AA range: 330-410
特异性
HNF6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
组织表达
Highly expressed in liver; lower expression in testis and skin.
信号通路
Maturity onset diabetes of the young;
功能
function:Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.,online information:Hepatocyte nuclear factors entry,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 CUT DNA-binding domain.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Binds DNA as a monomer.,tissue specificity:Highly expressed in liver; lower expression in testis and skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
