产品名称
ESRP2 Rabbit Polyclonal Antibody
蛋白名称
Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H6T0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6T0/entry
Mouse Swissprot No.
Q8K0G8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K0G8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941B2RYJ8
免疫原
Synthesized peptide derived from part region of human protein
特异性
ESRP2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
epithelial splicing regulatory protein 2(ESRP2) Homo sapiens ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009],
组织表达
Epithelial cell-specific.
功能
function:mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.,induction:Down-regulated during the epithelial-to-mesenchymal transition (EMT).,similarity:Belongs to the ESRP family.,similarity:Contains 3 RRM (RNA recognition motif) domains.,tissue specificity:Epithelial cell-specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
