产品名称
BC11B Rabbit Polyclonal Antibody
蛋白名称
B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9C0K0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9C0K0/entry
Mouse Swissprot No.
Q99PV8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99PV8
免疫原
Synthesized peptide derived from human protein . at AA range: 570-650
特异性
BC11B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
B-cell CLL/lymphoma 11B(BCL11B) Homo sapiens This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
组织表达
Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
功能
function:Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.,tissue specificity:Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
