产品名称
ESRP2 Rabbit Polyclonal Antibody
蛋白名称
Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H6T0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6T0/entry
Mouse Swissprot No.
Q8K0G8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K0G8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941B2RYJ8
免疫原
Synthesized peptide derived from part region of human protein
特异性
ESRP2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
epithelial splicing regulatory protein 2(ESRP2) Homo sapiens ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009],
组织表达
Epithelial cell-specific.
功能
function:mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.,induction:Down-regulated during the epithelial-to-mesenchymal transition (EMT).,similarity:Belongs to the ESRP family.,similarity:Contains 3 RRM (RNA recognition motif) domains.,tissue specificity:Epithelial cell-specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
