产品名称
TCHP Rabbit Polyclonal Antibody
蛋白名称
Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BT92
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BT92/entry
Mouse Swissprot No.
Q3TVW5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TVW5
免疫原
Synthesized peptide derived from part region of human protein
特异性
TCHP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.,similarity:Belongs to the TCHP family.,subunit:Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18.,
组织表达
Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Cell membrane . Mitochondrion . Cell junction, desmosome .
功能
function:May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.,similarity:Belongs to the TCHP family.,subunit:Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
