产品名称
DIRC2 Rabbit Polyclonal Antibody
蛋白名称
Disrupted in renal carcinoma protein 2 (Disrupted in renal cancer protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96SL1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96SL1/entry
Mouse Swissprot No.
Q8BFQ6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BFQ6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q66H95
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
DIRC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Expressed in proximal tubular cells of the kidney.
细胞定位
Lysosome membrane ; Multi-pass membrane protein .
功能
disease:A chromosomal aberration involving DIRC2 is found in familial renal cell carcinoma 1 (RCC1) [MIM:144700]. Translocation t(2;3)(q35;q21).,similarity:Belongs to the major facilitator superfamily.,tissue specificity:Ubiquitous. Expressed in proximal tubular cells of the kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
