产品名称
HEXI2 Rabbit Polyclonal Antibody
蛋白名称
Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96MH2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96MH2/entry
Mouse Swissprot No.
Q3TVI4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TVI4
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
HEXI2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
功能
domain:The coiled-coil domain mediates oligomerization.,function:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.,induction:Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).,similarity:Belongs to the HEXIM family.,subunit:Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.,tissue specificity:Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
