RM2684

Phospho-Rb (Thr373) (10A4) Rabbit Monoclonal Antibody

RB; pRb; OSRC; pp110; p105-Rb; PPP1R130

常规抗体

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic phosphopeptide corresponding to residues surrounding Thr373 of human Rb

WB: 1:5000 IHC: 1:100 ICC/IF: 1:100 IP: 1:20

110kDa

106kDa

-20°C/1 year

Rabbit

IgG

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Affinity Purification