产品名称
MINA Rabbit Polyclonal Antibody
基因名称
MINA MDIG MINA53 NO52
蛋白名称
MYC-induced nuclear antigen (Mineral dust-induced gene protein) (Nucleolar protein 52)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IUF8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IUF8/entry
Mouse Swissprot No.
Q8CD15
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CD15
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8CFC1
免疫原
Synthesized peptide derived from part region of human protein
特异性
MINA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008],
组织表达
Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
细胞定位
Nucleus . Nucleus, nucleolus .
功能
function:Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.,induction:Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.,sequence caution:Translated as Trp.,similarity:Belongs to the MINA53/NO66 family.,similarity:Contains 1 JmjC domain.,tissue specificity:Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
