产品名称
E2F7 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor E2F7 (E2F-7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96AV8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96AV8/entry
Mouse Swissprot No.
Q6S7F2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6S7F2
免疫原
Synthesized peptide derived from human protein . at AA range: 560-640
特异性
E2F7 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008],
功能
domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,similarity:Belongs to the E2F/DP family.,subunit:Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
