产品名称
WNT8B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q93098
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q93098/entry
Mouse Swissprot No.
Q9WUD6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUD6
免疫原
Synthesized peptide derived from part region of human protein
特异性
WNT8B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008],
组织表达
Expression is restricted to the brain, and more specifically to the forebrain.
细胞定位
Secreted, extracellular space, extracellular matrix.
信号通路
WNT;WNT-T CELLHedgehog;Melanogenesis;Pathways in cancer;Basal cell carcinoma;
功能
function:Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.,similarity:Belongs to the Wnt family.,tissue specificity:Expression is restricted to the brain, and more specifically to the forebrain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
