产品名称
CIC Rabbit Polyclonal Antibody
蛋白名称
Protein capicua homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96RK0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96RK0/entry
Mouse Swissprot No.
Q924A2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q924A2
免疫原
Synthesized peptide derived from human protein . at AA range: 550-630
特异性
CIC Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes
组织表达
Expressed in fetal brain.
功能
function:Transcriptional repressor which may play a role in development of the central nervous system (CNS).,miscellaneous:Expressed in medulloblastoma, a pediatric brain tumor which may arise from the granule cell lineage.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interact with ATXN1 and ATXN1L.,tissue specificity:Expressed in fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
