产品名称
E2F7 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor E2F7 (E2F-7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96AV8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96AV8/entry
Mouse Swissprot No.
Q6S7F2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6S7F2
免疫原
Synthesized peptide derived from human protein . at AA range: 560-640
特异性
E2F7 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008],
功能
domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,similarity:Belongs to the E2F/DP family.,subunit:Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
