产品名称
XRN1 Rabbit Polyclonal Antibody
蛋白名称
5'-3' exoribonuclease 1 (EC 3.1.11.-) (Strand-exchange protein 1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IZH2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZH2/entry
Mouse Swissprot No.
P97789
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97789
免疫原
Synthesized peptide derived from part region of human protein
特异性
XRN1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
细胞定位
Cytoplasm . Discrete foci at the inner surface of the cell membrane.
功能
function:Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). May act as a tumor suppressor protein in osteogenic sarcoma (OGS).,induction:By GDNF.,miscellaneous:Down-regulated in OGS biopsy.,similarity:Belongs to the 5'-3' exonuclease family.,subcellular location:Discrete foci at the inner surface of the cell membrane.,subunit:Associates with alpha and beta tubulins (By similarity). Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.,tissue specificity:Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
