产品名称
YAF2 Rabbit Polyclonal Antibody
蛋白名称
YY1-associated factor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IY57
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IY57/entry
Mouse Swissprot No.
Q99LW6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99LW6
免疫原
Synthesized peptide derived from part region of human protein
特异性
YAF2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016],
组织表达
Brain,Epithelium,Skeletal muscle,
功能
function:Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBP2-type zinc finger.,subunit:Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
