产品名称
AEBP1 Rabbit Polyclonal Antibody
蛋白名称
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IUX7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IUX7/entry
Mouse Swissprot No.
Q640N1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q640N1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941A2RUV9
免疫原
Synthesized peptide derived from part region of human protein. AA range: 780-810
特异性
AEBP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013],
组织表达
Expressed in osteoblast and visceral fat.
细胞定位
[Isoform 1]: Secreted .; [Isoform 2]: Cytoplasm . Nucleus .
功能
caution:This protein has lost active site residues and zinc-binding sites and so is unlikely to be catalytically active.,function:May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.,PTM:Phosphorylated by MAPK1 in vitro.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 F5/8 type C domain.,subunit:Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.,tissue specificity:Expressed in osteoblast and visceral fat.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
