产品名称
ANO3 Rabbit Polyclonal Antibody
基因名称
ANO3 C11orf25 TMEM16C GENX-3947
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/63982
Human Swissprot No.
Q9BYT9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BYT9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/228432
Mouse Swissprot No.
A2AHL1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AHL1
免疫原
Synthesized peptide derived from human ANO3 AA range: 518-568
特异性
This antibody detects endogenous levels of ANO3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],
组织表达
Highly expressed in the forebrain striatum.
细胞定位
Cell membrane ; Multi-pass membrane protein . Shows an intracellular localization. .
功能
function:May act as a calcium-activated chloride channel.,similarity:Belongs to the anoctamin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
