产品名称
CYFP1 Rabbit Polyclonal Antibody
蛋白名称
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7L576
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7L576/entry
Mouse Swissprot No.
Q7TMB8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TMB8
免疫原
Synthesized peptide derived from human protein . at AA range: 980-1060
特异性
CYFP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia.,subunit:Interacts with the active GTP-bound form of RAC1. Interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 (By similarity). Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth.,
组织表达
B-cell lymphoma,Bone marrow,Brain,Hepatoma,Lung,Placenta,
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell projection, lamellipodium . Cell projection, ruffle . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). .
信号通路
Regulates Actin and Cytoskeleton;
功能
function:Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia.,subunit:Interacts with the active GTP-bound form of RAC1. Interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 (By similarity). Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
