产品名称
TSH3 Rabbit Polyclonal Antibody
基因名称
TSHZ3 KIAA1474 TSH3 ZNF537
蛋白名称
Teashirt homolog 3 (Zinc finger protein 537)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q63HK5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q63HK5/entry
Mouse Swissprot No.
Q8CGV9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGV9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZKB9
免疫原
Synthesized peptide derived from part region of human protein
特异性
TSH3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016],
组织表达
Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656).
细胞定位
Nucleus . Cell projection, growth cone . Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. .
功能
function:Transcriptional regulator involved in developmental processes .,similarity:Belongs to the teashirt C2H2-type zinc-finger protein family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 5 C2H2-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
