产品名称
AKAP4 Rabbit Polyclonal Antibody
蛋白名称
A-kinase anchor protein 4 (AKAP-4) (A-kinase anchor protein 82 kDa) (AKAP 82) (hAKAP82) (Major sperm fibrous sheath protein) (HI) (Protein kinase A-anchoring protein 4) (PRKA4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5JQC9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5JQC9/entry
Mouse Swissprot No.
Q60662
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60662
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O35774
免疫原
Synthesized peptide derived from human protein . at AA range: 430-510
特异性
AKAP4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Testis specific; only expressed in round spermatids.
细胞定位
Cell projection, cilium, flagellum . Localizes to the principle piece of the sperm flagellum.
功能
developmental stage:Post-meiotic phase of spermatogenesis.,domain:RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:Major structural component of sperm fibrous sheath. Plays a role in sperm motility.,similarity:Belongs to the AKAP110 family.,subcellular location:Localizes to the principle piece of the sperm flagellum.,subunit:Interacts with PRKAR1A and PRKAR2A.,tissue specificity:Testis specific; only expressed in round spermatids.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
