产品名称
GA45B Rabbit Polyclonal Antibody
蛋白名称
Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75293
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75293/entry
Mouse Swissprot No.
P22339
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P22339
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
GA45B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008],
组织表达
Brain,Colon carcinoma,Lung carcinoma,
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;p53;
功能
function:Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
