产品名称
TAB3 Rabbit Polyclonal Antibody
蛋白名称
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N5C8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N5C8/entry
Mouse Swissprot No.
Q571K4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q571K4
免疫原
Synthesized peptide derived from part region of human protein
特异性
TAB3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Constitutively overexpressed in certain tumor tissues. ; [Isoform 1]: Major transcript. ; [Isoform 2]: Minor transcript.
细胞定位
nucleoplasm,cytoplasm,cytosol,plasma membrane,endosome membrane,extracellular exosome,
功能
function:Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.,PTM:Phosphorylated.,PTM:Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.,similarity:Contains 1 CUE domain.,similarity:Contains 1 RanBP2-type zinc finger.,subunit:Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3.,tissue specificity:Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
