产品名称
SIVA Rabbit Polyclonal Antibody
蛋白名称
Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15304
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15304/entry
Mouse Swissprot No.
O54926
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54926
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P59692
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
SIVA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
细胞定位
Cytoplasm . Nucleus . In the nucleus, accumulates in dot-like structures.
功能
cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
