产品名称
MK12 Rabbit Polyclonal Antibody
蛋白名称
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P53778
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P53778/entry
Mouse Swissprot No.
O08911
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08911
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63538
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
MK12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in skeletal muscle and heart.
细胞定位
Cytoplasm. Nucleus. Mitochondrion. Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Oocyte meiosis;VEGF;Toll_Like;NOD-like receptor;RIG-I-like receptor;T_Cell_Receptor;Fc epsilon RI;Leukocyte transendothelial migration;Neurotrophin;GnRH;Progesterone-mediated oocyte maturation;Amyotrophic lateral sclerosis (
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 magnesium ions.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by phosphorylation on threonine and tyrosine.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Mitochondrial when associated with SH3BP5.,subunit:Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5.,tissue specificity:Highly expressed in skeletal muscle and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
