RM1990

Drosha (14O19) Rabbit Monoclonal Antibody

RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

常规抗体

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic peptide of human Drosha

WB: 1:2000-1:10000 IHC: 1:20-1:50 ICC/IF: 1:100 FC: 1:20

159kDa

159kDa

-20°C/1 year

Rabbit

IgG

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Affinity Purification