BD-PN1608

MAGD1 Rabbit Polyclonal Antibody

常规抗体

MAGED1 NRAGE PP2250 PRO2292

Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

9500

Q9Y5V3

https://www.uniprot.org/uniprotkb/Q9Y5V3/entry

Q9QYH6

http://www.uniprot.org/uniprot/Q9QYH6

Q9ES73

http://www.uniprot.org/uniprot/O54941Q9ES73

Synthesized peptide derived from human protein . at AA range: 200-280

MAGD1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

85kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.

Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. .

Neurotrophin;

function:Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.,similarity:Contains 1 MAGE domain.,subcellular location:Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.,subunit:Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor.,tissue specificity:Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.