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ABL1 (12V14) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM1963
产品名称
ABL1 (12V14) Rabbit Monoclonal Antibody
别名
ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
类别
常规抗体
推荐应用
WB
反应种属
Human
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
免疫原
Recombinant protein of human ABL1
稀释度
WB: 1:1000 FC: 1:100
参考分子量
135kDa
预测分子量
123kDa
运输及保存条件
-20°C/1 year
宿主
Rabbit
同种型
IgG
背景介绍
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
纯化
Affinity Purification

Western blot analysis of extracts from HeLa cells using RM1963 at 1:1000.

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