产品名称
M3K12 Rabbit Polyclonal Antibody
蛋白名称
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q12852
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12852/entry
Mouse Swissprot No.
Q60700
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60700
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63796
免疫原
Synthesized peptide derived from human protein . at AA range: 730-810
特异性
M3K12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010],
组织表达
Highly expressed in brain and kidney.
细胞定位
Cytoplasm . Cell membrane . Behaves essentially as an integral membrane protein. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:Interacts with MBIP through the leucine-zipper motif.,function:May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.,PTM:Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MBIP.,tissue specificity:Highly expressed in brain and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
