BD-PN1592

JIP4 Rabbit Polyclonal Antibody

常规抗体

SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6

C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

9043

O60271

https://www.uniprot.org/uniprotkb/O60271/entry

Q58A65

http://www.uniprot.org/uniprot/Q58A65

Synthesized peptide derived from human protein . at AA range: 590-670

JIP4 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

145kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],

Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte. ; [Isoform 4]: Expressed in testis and in acute myeloid leukemia (AML) patients. ; [Isoform 3]: Expressed in testis.

Cytoplasm . Cytoplasm, perinuclear region . Lysosome membrane . Perinuclear distribution in response to stress signals such as UV radiation. .; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. .

function:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.,induction:Isoform 3 is increased in systemic sclerosis fibroblasts.,PTM:Phosphorylated by MAPK8 and MAPK14 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the JIP scaffold family.,subcellular location:Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.,subcellular location:Perinuclear distribution in response to stress signals such as UV radiation.,subunit:Homo-oligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.,tissue specificity:Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.