产品名称
CENPT Rabbit Polyclonal Antibody
基因名称
CENPT C16orf56 ICEN22
蛋白名称
Centromere protein T (CENP-T) (Interphase centromere complex protein 22)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96BT3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96BT3/entry
Mouse Swissprot No.
Q3TJM4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TJM4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q561R1
免疫原
Synthesized peptide derived from human protein . at AA range: 20-100
特异性
CENPT Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008],
组织表达
Brain,Epithelium,Lung,Uterus,
细胞定位
Nucleus. Chromosome, centromere . Chromosome, centromere, kinetochore . Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. .
功能
function:Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:Localizes exclusively in the kinetochore domain of centromeres.,subunit:Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
