产品名称
CENPO Rabbit Polyclonal Antibody
蛋白名称
Centromere protein O (CENP-O) (Interphase centromere complex protein 36)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BU64
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BU64/entry
Mouse Swissprot No.
Q8K015
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K015
免疫原
Synthesized peptide derived from human protein . at AA range: 220-300
特异性
CENPO Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
细胞定位
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
功能
function:Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.,subcellular location:Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.,subunit:Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
