产品名称
CCNL2 Rabbit Polyclonal Antibody
蛋白名称
Cyclin-L2 (Paneth cell-enhanced expression protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96S94
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96S94/entry
Mouse Swissprot No.
Q9JJA7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJA7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5I0H5
免疫原
Synthesized peptide derived from human protein . at AA range: 400-480
特异性
CCNL2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],
细胞定位
Nucleus speckle . Nucleus, nucleoplasm .
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
caution:It is uncertain whether Met-1 or Met-6 is the initiator.,domain:Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.,function:Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.,function:Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis.,induction:By interleukin-2.,online information:CC chemokine receptors entry,similarity:Belongs to the cyclin family. Cyclin L subfamily.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CDC2L1 or CDC2L2, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II.,tissue specificity:Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.,tissue specificity:Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
