产品名称
CCNG2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16589
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16589/entry
Mouse Swissprot No.
O08918
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08918
免疫原
Synthesized peptide derived from human protein . at AA range: 20-100
特异性
CCNG2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008],
组织表达
High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.
功能
developmental stage:Expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase.,function:May play a role in growth regulation and in negative regulation of cell cycle progesssion.,induction:Activated by actinomycin-D induced DNA damage.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin G subfamily.,tissue specificity:High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
