产品名称
B2L10 Rabbit Polyclonal Antibody
蛋白名称
Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HD36
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HD36/entry
Mouse Swissprot No.
Q9Z0F3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0F3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q99M66
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
B2L10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
细胞定位
Mitochondrion . Nucleus membrane . Endoplasmic reticulum . Cytoplasm, cytoskeleton, spindle . Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). .
功能
function:Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.,similarity:Belongs to the Bcl-2 family.,subunit:Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.,tissue specificity:Widely expressed in adult tissues. Preferentially expressed in the lungs, the liver and the kidneys.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
