产品名称
ADCY2 Rabbit Polyclonal Antibody
蛋白名称
Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q08462
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q08462/entry
Mouse Swissprot No.
Q80TL1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80TL1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P26769
免疫原
Synthesized peptide derived from human protein . at AA range: 490-570
特异性
ADCY2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008],
组织表达
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.
细胞定位
Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm .
信号通路
Purine metabolism;Calcium;Chemokine;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Dilated cardiomyopathy;
功能
catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
