产品名称
S39A6 Rabbit Polyclonal Antibody
蛋白名称
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13433
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13433/entry
Mouse Swissprot No.
Q8C145
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C145
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4V887
免疫原
Synthesized peptide derived from part region of human protein
特异性
S39A6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:May act as a zinc-influx transporter.,induction:Up-regulated by estrogen in breast cancer cells lines.,PTM:N-glycosylated.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,tissue specificity:Highly expressed in the breast, protate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
