产品名称
WNT2 Rabbit Polyclonal Antibody (Center)
别名
Protein Wnt-2, Int-1-like protein 1, Int-1-related protein, IRP, WNT2, INT1L1, IRP
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
P09544
特异性
This WNT2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 254-287 amino acids from the Central region of human WNT2.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
组织表达
Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
细胞定位
Secreted, extracellular space, extracellular matrix. Secreted
功能
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:
20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
