产品名称
ZN335 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H4Z2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H4Z2/entry
Mouse Swissprot No.
A2A5K6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2A5K6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941G3V893
免疫原
Synthesized peptide derived from part region of human protein
特异性
ZN335 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
zinc finger protein 335(ZNF335) Homo sapiens The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed.
功能
function:May regulate transcriptional activation through NCOA6.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 13 C2H2-type zinc fingers.,subunit:Interacts with NCOA6, but not with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR and PPARA.,tissue specificity:Relatively high expression in the skeletal muscle, thymus, placenta and blood. Moderate expression in the colon, kidney and lung. Low expression in the small intestine, heart, liver and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
