产品名称
PLXNB1 Rabbit Polyclonal Antibody (C-term)
别名
Plexin-B1, Semaphorin receptor SEP, PLXNB1, KIAA0407, PLXN5, SEP
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
O43157
特异性
This PLXNB1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1715-1749 amino acids from the C-terminal region of human PLXNB1.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
组织表达
Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted
功能
Receptor for SEMA4D (PubMed:
19843518, PubMed:
20877282, PubMed:
21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:
12196628, PubMed:
15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:
12198496).
