产品名称
ZN238 Rabbit Polyclonal Antibody
基因名称
ZNF238 RP58 TAZ1 ZBTB18
蛋白名称
Zinc finger protein 238 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger and BTB domain-containing protein 18) (Zinc finger protein C2H2-171)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99592
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99592/entry
Mouse Swissprot No.
Q9WUK6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUK6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JKY3
免疫原
Synthesized peptide derived from part region of human protein
特异性
ZN238 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],
组织表达
Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.
细胞定位
Nucleus. Associates with condensed chromatin.
功能
function:Sequence-specific DNA-binding protein with transcriptional repression activity. Binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core. May play a role in the organization of chromosomes in the nucleus.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 4 C2H2-type zinc fingers.,subcellular location:Associates with condensed chromatin.,subunit:Interacts with DNMT3A.,tissue specificity:Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
