BD-PB4930

RIOK3 Rabbit Polyclonal Antibody (Center)

Serine/threonine-protein kinase RIO3, RIO kinase 3, sudD homolog, RIOK3, SUDD

常规抗体

WB

Human, Mouse

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.

O14730

This RIOK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 146-179 amino acids from the Central region of human RIOK3.

WB~~1:1000

59kDa

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Rabbit

Rabbit IgG

Widely expressed..

Cytoplasm.

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).

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