BD-PB4923-NTRK3 Rabbit Polyclonal Antibody (Center)-现货抗体产品库武汉枢密脑科学技术有限公司

NTRK3 Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号

BD-PB4923

产品名称

NTRK3 Rabbit Polyclonal Antibody (Center)

别名

NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

存储缓冲液

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.

Human Swissprot No.

Q16288

特异性

This NTRK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 393-426 amino acids from the Central region of human NTRK3.

稀释度

FC~~1:25;WB~~1:1000

预测分子量

94kDa

运输及保存条件

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

宿主

Rabbit

同种型

Rabbit IgG

背景介绍

Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

组织表达

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain

细胞定位

Membrane; Single-pass type I membrane protein.

功能

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

期货

现货

Flow cytometric analysis of NIH-3T3 cells using NTRK3 Antibody (Center)(green) compared to an isotype control of rabbit IgG(blue). BD-PB4923 was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.

Western blot analysis of lysate from MCF-7 cell line, using NTRK3 Antibody (Center)at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.