BD-PB4895

TYK2 Rabbit Polyclonal Antibody (C-term)

Non-receptor tyrosine-protein kinase TYK2, TYK2

常规抗体

WB

Human, Mouse

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.

P29597

This TYK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 887-922 amino acids from the C-terminal region of human TYK2.

IHC-P~~1:100~500;WB~~1:1000

134kDa

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Rabbit

Rabbit IgG

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines

Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297). Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297). Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719). In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).

现货