产品名称
XDH Rabbit Polyclonal Antibody
蛋白名称
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P47989
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P47989/entry
Mouse Swissprot No.
Q00519
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q00519
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P22985
免疫原
Synthesized peptide derived from part region of human protein
特异性
XDH Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014],
组织表达
Detected in milk (at protein level).
细胞定位
Cytoplasm . Peroxisome . Secreted.
信号通路
Purine metabolism;Caffeine metabolism;Drug metabolism;
功能
catalytic activity:Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH.,catalytic activity:Xanthine + H(2)O + O(2) = urate + H(2)O(2).,catalytic activity:Xanthine + NAD(+) + H(2)O = urate + NADH.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,disease:Defects in XDH are the cause of xanthinuria type 1 (XU1) [MIM:278300]. Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol.,disease:May contribute to adult respiratory stress syndrome (ARDS) and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.,function:This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer. Interacts with BTN1A1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
