产品名称
CTSD(heavy chain) Rabbit Polyclonal Antibody (Center)
别名
Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
P07339
特异性
This CTSD(heavy chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 241-273 amino acids from the Central region of human CTSD(heavy chain).
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
组织表达
Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
细胞定位
Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)
功能
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:
27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
