产品名称
MME Rabbit Polyclonal Antibody (Center)
别名
Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
P08473
特异性
This MME antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 492-525 amino acids from the Central region of human MME.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers.
细胞定位
Cell membrane; Single-pass type II membrane protein
功能
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:
15283675, PubMed:
8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:
17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:
15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1- 32)) (PubMed:
2531377, PubMed:
2972276, PubMed:
16254193). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers (PubMed:
20876573).
